Bafuputsi ba Lefapha la Mechanical and Aerospace Engineering (MAE) ea Herbert Wertheim School of Engineering ba thehile mofuta o mocha oa hemodialysis membrane e entsoeng ka graphene oxide (GO), e leng ntho e entsoeng ka monoatomic layered.Ho lebeletsoe ho fetola ka ho feletseng phekolo ea liphio dialysis ka mamello.Tsoelo-pele ena e lumella "microchip dialyzer" hore e khomarele letlalo la mokuli.E sebetsa tlas'a khatello ea mali, e tla felisa pompo ea mali le potoloho ea mali ea extracorporeal, ho lumella dialysis e bolokehileng boiketlong ba ntlo ea hau.Ha ho bapisoa le lera le teng la polymer, ho kenella ha lera ke litekanyo tse peli tsa boholo bo phahameng, ho lumellana le mali, 'me ha ho bonolo ho lekanya joaloka li-membrane tsa polymer.
Moprofesa Knox T. Millsaps oa MAE le mofuputsi ea ka sehloohong oa morero oa membrane Saeed Moghaddam le sehlopha sa hae ba thehile ts'ebetso e ncha e amanang le ho iketsetsa le ho ntlafatsa thepa ea 'mele le lik'hemik'hale tsa GO nanoplatelets.Ts'ebetso ena e fetola feela likarolo tse 3 tsa GO hore e be likopano tse hlophisitsoeng hantle tsa nanosheet, ka hona li fihlellehe le ho khetha."Ka ho theha lesela le kenang ka mokhoa o hlakileng ho feta molekane oa lona oa tlhaho, e leng glomerular basement membrane (GBM) ea liphio, re bontšitse bokhoni bo boholo ba ho ikamahanya le li-nanomaterials, nanoengineering le molecular."Mogda Dr. Mu o boletse.
Boithuto ba tšebetso ea membrane maemong a hemodialysis bo hlahisitse litholoana tse khothatsang haholo.Li-coefficients tsa sieving tsa urea le cytochrome-c ke 0.5 le 0.4, ka ho latellana, tse lekaneng bakeng sa dialysis e liehang nako e telele ha li ntse li boloka ho feta 99% ea albumin;liphuputso tse mabapi le hemolysis, complement activation le coagulation li bontšitse hore li bapisoa le lisebelisoa tse teng tsa dialysis membrane Kapa li molemo ho feta ts'ebetso ea lisebelisoa tse teng tsa dialysis membrane.Liphetho tsa thuto ena li phatlalalitsoe ho Advanced Materials Interfaces (Hlakola 5, 2021) tlasa sehlooho se reng "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
Dr. Moghaddam o itse: “Re bontšitse ka mokhoa o ikhethang o ikopanyelitseng oa mosaic ea odara ea GO nanoplatelet, e ntlafatsang haholo boiteko ba lilemo tse leshome ba ho etsoa ha lera la graphene.”Ke sethala se sebetsang se ka ntlafatsang dialysis ea bosiu bo bobebe lapeng. ”Hajoale Dr. Moghaddam o ntse a sebetsa ho nts'etsopele ea li-microchips tse sebelisang li-membrane tsa GO tse ncha, tse tla atametsa lipatlisiso haufi le 'nete ea ho fana ka lisebelisoa tse aparoang tsa hemodialysis bakeng sa bakuli ba lefu la liphio.
Sengoliloeng sa Nature (March 2020) se itse: “Mokhatlo oa Lefatše oa Bophelo o hakanya hore batho ba ka bang limilione tse 1,2 ba shoa ka lebaka la ho hloleha ha liphio selemo le selemo [’me liketsahalo tsa lefu la renal la ho qetela (ESRD) li bakoa ke lefu la tsoekere le khatello ea mali]….Dialysis Motsoako oa mefokolo e sebetsang ea theknoloji le ho khoneha ho boetse ho bolela hore batho ba ka tlase ho halofo ea batho ba hlokang phekolo ba khona ho e fumana.Lisebelisoa tse aparoang tse nyane tse loketseng ke tharollo ea moruo ea ho eketsa litekanyetso tsa ho pholoha, haholo-holo ntlafatsong ea China.Dr. Moghaddam o itse: "Lera la rona ke karolo ea bohlokoa ea tsamaiso e nyenyane ea ho apara, e ka hlahisang mosebetsi oa ho hloekisa liphio, e leng ho ntlafatsa haholo matšeliso le ho khoneha lefatšeng ka bophara."
"Khatelo-pele e kholo kalafong ea bakuli ba nang le hemodialysis le ho hloleha ha renal e lekantsoe ke theknoloji ea membrane.Theknoloji ea Membrane ha e e-s'o etse tsoelo-pele e kholo lilemong tse mashome a seng makae tse fetileng.Tsoelo-pele ea mantlha ea theknoloji ea membrane e hloka ntlafatso ea dialysis ea renal.Thepa e kenang haholo le e khethang, joalo ka ultra-thin graphene oxide membrane e ntlafalitsoeng mona, e ka fetola paradigm.Li-membrane tse tšesaane tse tšesaane haholo ha li khone ho bona li-dialyzers tse nyane feela, empa hape le lisebelisoa tsa 'nete tse nkehang habonolo, ka tsela eo li ntlafatsa boleng ba bophelo le ponelopele ea mokuli. ”James L. McGrath o itse ke moprofesa oa boenjiniere ba likokoana-hloko Univesithing ea Rochester le moqapi-'moho le eena oa theknoloji e ncha ea lesela la silicon e nyenyane haholo bakeng sa lisebelisoa tse sa tšoaneng tsa likokoana-hloko (Nature, 2007).
Patlisiso ena e tšehelitsoe ka lichelete ke National Institute of Biomedical Imaging and Bioengineering (NIBIB) tlasa Mekhatlo ea Naha ea Bophelo bo Botle.Sehlopha sa Dr. Moghaddam se kenyelletsa Dr. Richard P. Rode, setsebi sa postdoctoral ho UF MAE, Dr. Thomas R. Gaborski (mofuputsi-hlooho-hlooho), Daniel Ornt, MD (mofuputsi-'moho le eena), le Henry C oa Lefapha la Biomedical. Boenjiniere, Setsi sa Theknoloji sa Rochester.Ngaka Chung le Hayley N. Miller.
Dr. Moghaddam ke setho sa UF Interdisciplinary Microsystems Group 'me o etella pele Nanostructured Energy Systems Laboratory (NESLabs), eo morero oa eona e leng ho ntlafatsa boemo ba tsebo ea nanoengineering ea mehaho e sebetsang ea porous le micro/nanoscale transmission physics.O kopanya lithuto tse ngata tsa boenjiniere le saense ho utloisisa hamolemo fisiks ea phetisetso ea micro/nano-scale le ho nts'etsapele meaho le lits'ebetso tsa moloko o latelang ka ts'ebetso e phahameng le ts'ebetso e ntle.
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